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KMID : 0384320120330040190
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Korean Journal of Family Medicine
2012 Volume.33 No. 4 p.190 ~ p.196
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Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study
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Park Byoung-Jin
Lee Yong-Jae
Lee Hye-Ree
Jung Dong-Hyuk
Na Ha-Young
Kim Hong-Bae
Shim Jae-Yong
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Abstract
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Background: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome.
Methods: We performed a randomized, double-blind, placebo-controlled, single-center study in 60 subjects who were not taking drugs that could affect metabolic and vascular functions. Subjects were randomized into either a KRG (4.5 g/d) group or a placebo group for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, and brachial-ankle pulse wave velocity (baPWV) at the initial (week 0) and fi nal (week 12) visits.
Results: A total of 48 subjects successfully completed the study protocol. Oral administration of KRG did not signifi cantly affect blood pressure, oxidative orinfl ammatory markers, or baPWV.
Conclusion: We found no evidence that KRG had an effect on blood pressure, lipid profi le, oxidized low density lipoprotein, fasting blood glucose, or arterial stiffness in subjects with metabolic syndrome. These findings warrant subsequent longer-term prospective clinical investigations with a larger population. Trial Registration: Clinical Trials.gov Identifier: NCT00976274
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KEYWORD
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Panax ginseng, Metabolic Syndrome, Randomized Controlled Trial
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